Nuclear departure controls pluripotency exit
نویسندگان
چکیده
منابع مشابه
Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm
Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming, and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2013
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3504